C. neoformans gene expression in DMEM of WT and rim101 mutant cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Cryptococcus neoformans
SUBMITTER: Teresa O'Meara
PROVIDER: E-GEOD-43189 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.
O'Meara Teresa R TR Holmer Stephanie M SM Selvig Kyla K Dietrich Fred F Alspaugh J Andrew JA
mBio 20130115 1
<h4>Unlabelled</h4>Infectious microorganisms often play a role in modulating the immune responses of their infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 transcription factor to regulate cell wall composition and the host-pathogen interface. In the absence of Rim101, C. neoformans exhibits an altered cell surface in response to host signals, generating an excessive and ineffective immune response that results in accelerated host death. This host immune res ...[more]
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