Transcriptional profiles of psychostimulant reinforcement in rats

ABSTRACT: Drug-induced alterations in transcriptional regulation play a central role in establishing the persistent neuroplasticities that occur during drug addiction. Additionally, changes in gene expression associated with drug administration provide valuable insight into the molecular basis of drug abuse. The molecular mechanisms that underlie susceptibility to psychostimulant addiction remain unknown. Identifying the common gene transcriptional responses to psychostimulants can provide a mechanistic insight to elucidate the molecular nature of drug dependence. Male Wistar rats (4 weeks old) were acclimatized for a week to their housing conditions prior to experiments. Thereafter, they were divided into two groups: (cohort 1) 4 groups of rats (n=12 rats per group) given saline only (i.p., "d

ORGANISM(S): Rattus norvegicus

SUBMITTER: Minsoo Noh 

PROVIDER: E-GEOD-43748 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress