Expression profiling of brain structures of dependent and non-dependent rats self-administering alcohol and naive controls

ABSTRACT: Rats were trained to orally self-administer alcohol in a concurrent, two-lever, free-choice contingency using a modification of the sweet solution fading procedure (O'Dell et al., 2004; Roberts et al., 2000; Vendruscolo et al., 2012). Following acquisition of self-administration, rats were allowed to self-administer unsweetened alcohol (10%) for 4 weeks and were then assigned to two groups matched by levels of responding: one group (dependent group) was exposed to chronic, intermittent ethanol vapors for 4 weeks to induce dependence; the other group (nondependent group) was not exposed to ethanol vapor. After a month of vapor exposure, rats were again tested during acute withdrawal (6-8 hours after removal from the vapor chambers) until stable levels of alcohol intake were achieved. As exp

ORGANISM(S): Rattus norvegicus

SUBMITTER: William Shin 

PROVIDER: E-GEOD-60966 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress