A DEVELOPMENTAL SYSTEMS BIOLOGY APPROACH TO DEFINE THE MOLECULAR FRAMEWORK OF THE HEMATOPOIETIC STEM CELL NICHE

ABSTRACT: Hematopoietic stem cells (HSCs) are at the basis of the hematopoietic hierarchy. Their ability to self-renew and differentiate is strictly controlled by molecular signals produced by their surrounding micorenvironments composed of stromal cells. HSCs first emerge in the AGM (Aorta Gonads Mesonephros) region, amplify in the fetal liver (FL) and are maintained in the adult bone marrow (BM). To further characterize the molecular program of the HSC niches, we have compared the global transcriptome of HSC-supportive and non-supportive stromal clones established from the AGM, FL and BM. Hematopoietic stem cells (HSCs) are at the basis of the hematopoietic hierarchy. Their ability to self-renew and differentiate is strictly controlled by molecular signals produced by their surrounding micorenviro

ORGANISM(S): Mus musculus

SUBMITTER: Florent Dumont 

PROVIDER: E-GEOD-44181 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress