Transcription profiling of human airway epithelial cells infected with Pseudomonas aeruginosa wild type and rsmA mutant dentifies human transcription factors KLF2 and KLF6 as targets of the P. aeruginosa type III exoenzymes S and Y.

ABSTRACT: Global expression profiling of airway epithelial cells infected with Pseudomonas aeruginosa and the rsmA mutant. Recent work in our laboratory investigated the impact of RsmA on a number of airway epithelial cell phenotypes including actin depolymerization, cytotoxicity and invasion. These cellular phenotypes were influenced by the positive effect of RsmA on the expression of the TTSS in P. aeruginosa (Mulcahy et al. 2006. Infect. Immun.). Pseudomonas aeruginosa is an important opportunistic pathogen which is capable of causing both acute and chronic infections in immunocompromised patients. Successful adaptation of the bacterium to its host environment relies on the ability of the organism to tightly regulate gene expression. RsmA, a small RNA-binding ; protein, controls the expression of

ORGANISM(S): Homo sapiens

DISEASE(S): Pseudomonas aeruginosa rsmA mutant infected

SUBMITTER: Fergal O'Gara 

PROVIDER: E-GEOD-4485 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress