Expression analysis of Streptococcus mutans UA159 under Hyperosmotic stress environment

ABSTRACT: Oral streptococci metabolize carbohydrate to produce organic acids, not only decrease the environmental pH, but also increase osmolality of dental plaque fluid due to tooth demineralization and consequent calcium and phosphate accumulation. Thus, to persevere in the dental plaque, acidogenic bacteria should evolve sophisticated molecular machineries to counter the detrimental effect of elevated osmolality. This study was aimed to obtain a global view on strategies taken by streptococcus mutans to deal with physiologically relevant elevated osmolality, and preserves within a cariogenic dental plaque. We investigated phenotypic change of S. mutans biofilm upon sub-lethal level of hyperosmotic challenge. We found that hyperosmotic condition was able to initiate S. mutans biofilm dispersal by

ORGANISM(S): Streptococcus mutans UA159

SUBMITTER: Yulong Niu 

PROVIDER: E-GEOD-47170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress