Differential LINE-1 retrotransposition in induced pluripotent stem cells between humans and great apes

ABSTRACT: Understanding cellular and molecular differences between human and non-human primates (NHPs) is essential to the basic comprehension of the evolution and diversity of our own species. Until now, preserved tissues have been the main source of most comparative studies between humans, chimpanzees (Pan troglodytes) and bonobos (Pan paniscus). However, these tissue samples do not fairly represent the distinctive traits of live cell behavior, are not amenable to genetic manipulation and do not allow translation of observed differences into phenotypical divergence. We hypothesized that induced pluripotent stem cells (iPSCs) could provide a unique biological resource to elucidate relevant phenotypical differences between human and the great apes and that those differences could have potential adap

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Benner 

PROVIDER: E-GEOD-47626 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress