Cross-species gene expression analysis of species-specific differences in preclinical assessment of pharmaceutical compounds (human)

ABSTRACT: Significant qualitative and quantitative differences exist between humans and the animal models used in research. However, significant quantitative and qualitative differences exist between humans and the animal models used in research. This is as a result of genetic variation between human and the laboratory animal. Therefore the development of a system that would allow the assessment of all molecular differences between species after drug exposure would have a significant impact on drug evaluation for toxicity and efficacy. Here we describe a cross-species microarray methodology that identifies and selects orthologous probes after cross-species sequence comparison to develop an orthologous cross-species gene expression analysis tool. The assumptions made by the use of this orthologous ge

ORGANISM(S): Homo sapiens

SUBMITTER: John Okyere 

PROVIDER: E-GEOD-47970 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress