Regulation of NF-κB signaling by miR-21-3p and miR-27a-5p in Response to Oxidized Phospholipids in Human Aortic Endothelial Cells

ABSTRACT: The transition of the endothelium to a pro-inflammatory state is key to progression of chronic inflammatory diseases including rheumatoid arthritis, chronic bowel disease and atherosclerosis. In atherosclerosis it is hypothesized that low density lipoproteins (LDL) that become trapped in the intima of the blood vessels are oxidized to minimally modified LDL (mmLDL) and that these serve as an important contributing factors to endothelial dysfunction. Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (OX-PAPC), a model of the active phospholipid components of mmLDL affects the expression of hundreds of genes involved in inflammatory and other biological processes in human aortic endothelial cells (HAECs). We hypothesized that microRNAs (miRNAs) partially regulate this re

ORGANISM(S): Homo sapiens

SUBMITTER: Mete Civelek 

PROVIDER: E-GEOD-48006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress