The conserved organization of the human and mouse transcriptomes

ABSTRACT: We characterized by RNA-seq the transcriptional profiles of a large and heterogeneous collection of mouse tissues, augmenting the mouse transcriptome with thousands of novel transcript candidates. Comparison with transcriptome profiles obtained in human cell lines reveals substantial conservation of transcriptional programs, and uncovers a distinct class of genes with levels of expression across cell types and species, that have been constrained early in vertebrate evolution. This core set of genes capture a substantial and constant fraction of the transcriptional output of mammalian cells, and participates in basic functional and structural housekeeping processes common to all cell types. Perturbation of these constrained genes is associated with significant phenotypes including embryonic

ORGANISM(S): Homo sapiens

SUBMITTER: ENCODE DCC 

PROVIDER: E-GEOD-49417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress