Primate transcript and protein expression levels evolve under compensatory selection pressures

ABSTRACT: Variation in gene regulation is thought to have played an important role in the evolution of primates, and many studies have documented differences in mRNA expression levels across primate species. However, it is not yet known to what extent measurements of divergence in mRNA levels reflect divergence in protein expression levels, which are more directly tied to phenotypic differences. To address this question, we used high-resolution, quantitative mass spectrometry to collect thousands of protein expression measurements from human, chimpanzee, and rhesus macaque lymphoblastoid cell lines (LCLs). We also used RNA sequencing to collect transcript expression data from the same samples. Considering the two datasets jointly we found that there is much more inter-species divergence at the mRNA

ORGANISM(S): Pan troglodytes

SUBMITTER: Darren Cusanovich 

PROVIDER: E-GEOD-49682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress