Genome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs [methylation]

ABSTRACT: Background: Age-related physiological, biochemical and functional changes in mammalian skeletal muscle have been shown to begin at the mid-point of the lifespan. However, the underlying changes in DNA methylation that occur during this turning point of the muscle aging process have not been clarified. To explore age-related genomic methylation changes in skeletal muscle, we employed young (0.5 years old) and middle-aged (7 years old) pigs as models to survey genome-wide DNA methylation in the longissimus dorsi muscle using a methylated DNA immunoprecipitation sequencing approach. Results: We observed a tendency toward a global loss of DNA methylation in the gene-body region of the skeletal muscle of the middle-aged pigs compared with the young group. We determined the genome-wide gene expr

ORGANISM(S): Sus scrofa

SUBMITTER: Mingzhou Li 

PROVIDER: E-GEOD-50716 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress