Tgif1 regulates quiescence and self-renewal signaling pathways of hematopoietic stem cells (HSCs)

ABSTRACT: In this study we demonstrate that Tgif1 has a role in HSCs maintenance, self-renewal and quiescence. RNA sequencing data of LSK cells (HSCs enriched cell population) from Tgif1-/- and wild type mice implicates that multiple pathways involved in HSC quiescence and self-renewal are disturbed in Tgif1 deficient mice. RNA expression profiles of wild type (WT) and Tgif1-/- LSK cells were generated by RNA sequencing, in triplicate, using Illumina HiSeq 2000.

ORGANISM(S): Mus musculus

SUBMITTER: Yan Guo 

PROVIDER: E-GEOD-50739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress