Gene expression in liver tissue from Ghrh-KO and normal (wild-type) mice

ABSTRACT: The hypothalamus has recently emerged as a key regulator of metabolism and aging in mammals. We have examined the impact of targeted disruption of hypothalamic hypophysiotropic peptide: Growth Hormone-releasing Hormone (GHRH) in mice on longevity, and the putative mechanisms of delayed aging. GHRH knockout (KO) mice are remarkably long-lived and in comparison to genetically normal (wild type) animals exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress resistance, and insulin signaling. These mutant mice also have increased adiponectin levels and alterations in glucose homeostasis consistent with the removal of the counter-insulin effects of GH. While these effects overlap with those of caloric restriction (CR), we show that effects of CR and the

ORGANISM(S): Mus musculus

SUBMITTER: William Swindell 

PROVIDER: E-GEOD-51108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress