Inflammatory bowel disease risk loci overlap with DNA regulatory regions in immune cells and intestinal epithelium

ABSTRACT: Background & Aims: The contribution of genetics to the pathogenesis of inflammatory bowel disease (IBD) has been established by twin studies, targeted sequencing and genome-wide association studies (GWASs). This has yielded a plethora of risk loci with an aim to identify causal variants. Research on the genetic components of IBD has mainly focused on protein coding genes, thereby omitting other functional elements in the human genome i.e. the regulatory regions. Methods: Using acetylated histone 3 lysine 27 (H3K27ac) chromatin immunoprecipitation and sequencing (ChIP-seq), we identified tens of thousands of potential regulatory regions that are active in intestinal epithelium and immune cells, the main cell types involved in IBD. We correlated these regions with susceptibility loci for IBD

ORGANISM(S): Homo sapiens

SUBMITTER: Michal Mokry 

PROVIDER: E-GEOD-51425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress