CTCF/CP190 and ISWI dependent regulation of nucleosome occupancy [ChIP-seq]
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Marek Bartkuhn
PROVIDER: E-GEOD-51598 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking.
Bohla Dorte D Herold Martin M Panzer Imke I Buxa Melanie K MK Ali Tamer T Demmers Jeroen J Krüger Marcus M Scharfe Maren M Jarek Michael M Bartkuhn Marek M Renkawitz Rainer R
PloS one 20140923 9
Chromatin insulators of higher eukaryotes functionally divide the genome into active and inactive domains. Furthermore, insulators regulate enhancer/promoter communication, which is evident from the Drosophila bithorax locus in which a multitude of regulatory elements control segment specific gene activity. Centrosomal protein 190 (CP190) is targeted to insulators by CTCF or other insulator DNA-binding factors. Chromatin analyses revealed that insulators are characterized by open and nucleosome ...[more]
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