Kinetoplastid-specific histone variant functions are conserved in Leishmania major

ABSTRACT: Protein-coding genes in kinetoplastid protists are transcribed from polycistronic arrays, yielding RNA precursors which are processed to form mature transcripts bearing a 5M-bM-^@M-^Y spliced leader (SL) and 3M-bM-^@M-^Y poly(A) tract. Regions of transcription initiation and termination lack known eukaryotic promoter and terminator elements, and current data suggest that transcription is instead regulated predominantly through epigenetic mechanisms. Several epigenetic marks, including histone modifications, histone variants, and an atypical DNA modification known as base J have been localized to regions of transcription initiation or termination in Trypanosoma brucei, Trypanosoma cruzi, and/or Leishmania major. Despite this conservation, the phenotypes of base J mutants vary significantly

ORGANISM(S): Leishmania major

SUBMITTER: Gowthaman Ramasamy 

PROVIDER: E-GEOD-51737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress