Leukocyte gene expression variation as a function of chronic caregiving stress

ABSTRACT: This study explored how chronic stress influences the activity of signaling pathways that regulate inflammation in the human monocyte transcriptome. The sample consisted of 33 adults caring for a family member with glioblastoma, a terminal brain cancer, and 47 control subjects whose lives were free of major stressors. The subjects were assessed on four occasions across an eight-month period. Relative to controls, caregivers’ monocytes showed increased expression of genes bearing response elements for nuclear-factor kappa B, a key pro-inflammatory transcription factor in monocytes. Simultaneously, caregivers showed reduced expression of genes with response elements for the glucocorticoid receptor, a transcription factor that conveys anti-inflammatory signals to monocytes. These transcriptio

ORGANISM(S): Homo sapiens

SUBMITTER: Steve Cole 

PROVIDER: E-GEOD-52319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress