Down-regulation as the dominant hippocampal gene expression profile with voluntary resistance wheel running by DNA microarray analysis

ABSTRACT: Exercise improves brain function enhancing neuronal plasticity and cognitive enhancement. For voluntary resistance wheel running (RWR) exercise, with a load of 30% of body weight, we reported enhancement of neurogenesis and spatial memory associated with hippocampal brain-derived neurotrophic factor (BDNF) signaling compared to wheel running (WR) without a load (Lee et al., 2012; Lee et al., 2013). Despite these new evidences, mechanisms for RWR-induced improvement of hippocampal function remained to be clarified. In the present study, we have utilized the high-throughput DNA microarray approach to gain deep insight into molecular mechanisms underlying these changes that could be novel targets of RWR-induced hippocampal plasticity. To do so, whole genome (4x44K) high-density oligonucleotid

ORGANISM(S): Rattus norvegicus

SUBMITTER: Randeep Rakwal 

PROVIDER: E-GEOD-52516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress