Left ventricle transcriptomic analysis reveals the initial decline in VO2peak from its lifetime apex associates with connective tissue accumulation

ABSTRACT: Peak oxygen consumption (VO2peak) strongly predicts morbidity and mortality better than other established risk factors, yet all mechanisms associated with its age-related decline are unknown. Our lab has shown that VO2peak first begins to decrease at the same age of 19 weeks old in Wistar in both sedentary and wheel-running, female Wistar rats. Here, we employed RNA-sequencing to determine the extent to which transcriptomic alterations in the left ventricle associate with age-related decreases in VO2peak. Transcriptomic comparisons were made within both sedentary (SED) and wheel-running (RUN) rats between 19 and 27 wks (n= 5-8/group).

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tom Childs 

PROVIDER: E-MTAB-5223 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress