Genome-wide transcriptional analysis of HT1080 cells stably transfected with PTK7 constructs

ABSTRACT: Full-length membrane PTK7 and its N-terminal and C-terminal proteolytic fragments induced differential transcriptional profiles in HT1080 cells. Pseudokinase PTK7 is an essential regulator of planar cell polarity (PCP) and directional cell motility in the course of vertebrate development and embryogenesis, and regulates both the non-canonical Wnt/PCP and canonical Wnt pathways. In contrast to its well-appreciated, crucial role in embryo development, the functional importance of the intact full-length PTK7 in malignancy is still a matter of debate. In humans, the full-length membrane PTK7 consists of seven extracellular immunoglobulin-like (Ig) domains, a transmembrane region, a juxtamembrane region and a catalytically inert cytoplasmic tyrosine kinase (PTK) domain. Because pericellular pro

ORGANISM(S): Homo sapiens

SUBMITTER: Vladislav Golubkov 

PROVIDER: E-GEOD-53340 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress