Microarray profiling of gene expression in ageing murine skeletal muscles

ABSTRACT: We have previously documented a time-course of sarcopenia development in female C57Bl/6J mice, with significant loss of quadriceps muscle mass by 24 m that is more pronounced by 27-29 m. The present study used gastrocnemius muscles from female C57Bl/6J mice aged 3, 15, 24 and 29 months to investigate the expression of genes that coincide with, or potentially precede, muscle loss. The microarray analyses of ageing gastrocnemius muscle indicated that the Functional Theme Protein catabolism was first discernable in 15 and 24 age contrast and then again in the age contrast between 24 m and 29 m. A common Functional Theme in all age contrasts from the microarray analysis was extracellular matrix suggesting continual remodeling of skeletal muscle during ageing. Metabolic traits, particularly th

ORGANISM(S): Mus musculus

SUBMITTER: Tea Shavlakadze 

PROVIDER: E-GEOD-53959 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress