Netrin-1 facilitates somatic cell reprogramming by limiting Dcc pro-apoptotic activity.

ABSTRACT: The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. However, the relative flaws in the understanding of the molecular mechanisms promoting or limiting reprogramming still hinder the efficient generation of high quality iPS cells. Whereas modulation of the initial Oct4, Sox2, Klf4 and c-Myc (OSKM) cocktail with new transcription factors has been extensively documented, comparatively little is known about soluble molecules promoting the process, even if such recombinant factors could be highly valuable for therapeutic applications. In this study we developed a large-scale identification method to uncover novel programmed cell death (PCD)-related mechanisms limiting somatic cell reprogramming to pluripotency (SCRP). We identified Netrin-1 and

ORGANISM(S): Mus musculus

SUBMITTER: Fabrice Lavial 

PROVIDER: E-GEOD-54107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress