Global gene expression differences between blood- and lymphatic-specific endothelial colony forming cells

ABSTRACT: The identification of circulating endothelial progenitor cells has led to speculation regarding their origin as well as their contribution to neovascular development. Two distinct types of endothelium make up the blood and lymphatic vessel system. However, it has yet to be determined whether there are distinct lymphatic-specific circulating endothelial progenitor cells. We isolated circulating endothelial colony forming cells (ECFCs) from whole peripheral blood. These cells are endothelial in nature, as defined by their expression of endothelial markers and their ability to undergo capillary morphogenesis in three-dimensional culture. A subset of isolated colonies express markers of lymphatic endothelium, including VEGFR-3 and Prox-1, with low levels of VEGFR-1, a blood endothelial marker,

ORGANISM(S): Homo sapiens

SUBMITTER: Terri DiMaio 

PROVIDER: E-GEOD-54416 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress