Early Events in Hematopoietic Cells Reprogramming into iPS Cells

ABSTRACT: Fibroblasts are the most commonly used model in probing the complex process of somatic reprogramming. Although hematopoietic cells represents a more  convenient and accesible/ or “an excellent alternative” starting cell type, the molecular mechanisms in hematopoietic reprogramming are poorly defined. In the present study, we showed that hematopoietic stem and progenitor cells (HSPCs) with long term repopulating potential, among several HSPC populations,  are more amenable for reprogramming, and exhibit an efficient induction of transcriptional program involved in the promation of cell prolifieration and inhibition of apoptosis. In sharp comparison with fibroblasts, HSPCs possess distinct requirements for the activation of Tgf-b and wnt pathways in the initiation phase of reprograming, whic

ORGANISM(S): Mus musculus

SUBMITTER: Lan Kang 

PROVIDER: E-GEOD-54462 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress