TIA proteins drives global and specific translational repression of genes linked to the cell-cycle progression and DNA replication/repair

ABSTRACT: The reduction of T-cell intracellular antigen (TIA) proteins in transformed cells leads to the acquisition of aberrant cellular phenotypes promoting uncontrolled cell proliferation and tumor growth. Here we show that global and specific translational rates are regulatory gene events that contribute markedly to the acquisition of above cellular phenotypes. For example, we observe a significant increase of ribosomal population and translational machinery components in TIA-reduced HeLa cells. Polysomal microarray analysis shows specific changes at both the transcript and translational level following TIA reduction, identifying translationally regulated mRNAs that are not transcriptionally regulated which seem to be prevalent for the adaptation to the new environmental conditions. Validation o

ORGANISM(S): Homo sapiens

SUBMITTER: Juan Oliveros 

PROVIDER: E-GEOD-54540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress