RiboMeth-seq: High-throughput mapping of ribose methylations in RNA at single-nucleotide resolution

ABSTRACT: The major information-carrying macromolecules in the cell, DNA, RNA, and protein, carry an additional layer of information on top of their sequence in the form of modifications of residues. The modifications provide additional functional groups and impact the structure and function of the molecules. Cellular RNA molecules contain more than 100 different modifications and are found in all domains of life and in all major classes of RNA in eukaryotic organisms. Together these modifications constitute the epitranscriptome of which two-thirds are methylations with 2’-O methylation of the ribose moiety of the nucleotide as the most abundant. Many aspects of ribose methylation are underexplored because the existing methods for their detection are laborious and can only address a few modification

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Ulf Birkedal 

PROVIDER: E-GEOD-54655 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress