Transcription profiling of rat arteries from animals with salt induced hypertensive disease results in over expression of matricellular genes in cerebral arteries
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Karen Lounsbury
PROVIDER: E-GEOD-5488 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genes overexpressed in cerebral arteries following salt-induced hypertensive disease are regulated by angiotensin II, JunB, and CREB.
Rose Patricia P Bond Jeffrey J Tighe Scott S Toth Michael J MJ Wellman Theresa L TL Briso de Montiano Eva Maria EM Lewinter Martin M MM Lounsbury Karen M KM
American journal of physiology. Heart and circulatory physiology 20071221 2
Although changes in gene expression are necessary for arterial remodeling during hypertension, the genes altered and their mechanisms of regulation remain uncertain. The goal of this study was to identify cerebral artery genes altered by hypertension and define signaling pathways important in their regulation. Intact cerebral arteries from Dahl salt-sensitive normotensive and hypertensive high-salt (HS) rats were examined by immunostaining, revealing an increased phosphorylation of extracellular ...[more]
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