Microarray-based gene expression of rabbit basilar artery smooth muscle cells exposed to hemodynamic insult

ABSTRACT: High-flow causes the remodeling of arteries, in which smooth muscle cells play an important role. To know the profile of smooth muscle gene expression under high-flow conditions in vivo, flow of rabbit basilar artery was increased by ligation of both common carotid arteries. Microarrays were performed to profile the gene expression of smooth muscle cells isolated from rabbit basilar artery. Expression profiles indicate 43603 differentially expressed genes in smooth muscle cells exposed to high-flow insult compared with the sham control, of which 1470 genes were upregulated and 780 genes downregulated using 2 fold-changes and P<0.05 as a cut-off. Bilateral common carotid arteries of female New Zealand White rabbits were ligated to increase vascular flow.The control group was performed the s

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: Zhaolong Zhang 

PROVIDER: E-GEOD-61212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress