Allele-specific binding of ZFP57 in the regulation of imprinted and mono-allelic expression

ABSTRACT: Selective maintenance of genomic methylation imprints during pre-implantation development is required for parental origin-specific expression of imprinted genes. The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary for maintaining the DNA methylation memory at multiple imprinting control regions (ICRs) in early mouse embryos and ES cells. Maternal-zygotic deletion of ZFP57 in mice presents a highly penetrant phenotype with no animals surviving to birth. In addition, several cases of human transient neonatal diabetes (TND) are associated with somatic mutations in ZFP57 coding sequence. Here we comprehensively map sequence-specific ZFP57 binding sites in an allele-specific manner using hybrid ES cell lines from reciprocal crosses between C57BL/6J and Cast/EiJ mice assigning

ORGANISM(S): Mus musculus

SUBMITTER: Felix Krueger 

PROVIDER: E-GEOD-55382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress