Radiation-induced bystander effects and gene expression in cells deficient for RAD9

ABSTRACT: Background: The radiation bystander response is an important component of the overall response of cells to radiation and critical to understanding health risks of radiation exposure to humans. The mechanism of radiation response includes inter-cellular signaling and intra-cellular communication by which the bystander signal is propagated. Methods: We measured the bystander response to 1Gy a-particle radiation in Mrad9-/- mouse stem cells and H1299shRAD9 cells, using chromosomal aberration and micronucleus formation as DNA damage endpoints. In the H1299 model we used whole genome microarray analyses to profile the transcriptome of irradiated and bystander cells. Results: We investigated the role of RAD9 in the bystander response and showed that depletion or mutation of RAD9 had an effect

ORGANISM(S): Homo sapiens

SUBMITTER: Shanaz Ghandhi 

PROVIDER: E-GEOD-55869 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress