Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MeDIP chip from ZOS and ZOSM osteosarcoma cell lines

ABSTRACT: Epigenetic change of genes expression, including hypomethylation-linked activation of oncogenes and hypermethylation-associated inactivation of tumor suppressor genes, can affect almost all the cellular signaling pathways that participate in cancer initiation and progression. Unlike genetic alterations, epigenetic changes are potentially reversible, making them attractive and promising targets for therapeutic intervention. Studies indicated that abnormal DNA methylation is involved in dysregulation of cell cycle, apoptosis, proliferation and differentiation of osteosarcoma. However, epigenetic mechanisms of osteosarcoma metastasis remain largely unknown. MeDIP chips are performed in ZOS and ZOSM—two syngeneic primary human osteosarcoma cell lines with low and high metastatic potential which are established in our lab

ORGANISM(S): Homo sapiens

SUBMITTER: Jinchang Lu 

PROVIDER: E-GEOD-55961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-κB signaling.

Lu Jinchang J   Song Guohui G   Tang Qinglian Q   Zou Changye C   Han Feng F   Zhao Zhiqiang Z   Yong Bicheng B   Yin Junqiang J   Xu Huaiyuan H   Xie Xianbiao X   Kang Tiebang T   Lam YingLee Y   Yang Huiling H   Shen Jingnan J   Wang Jin J  

The Journal of clinical investigation 20150330 5

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma development; however, the epigenetic mechanisms that are involved in metastasis are not yet clear. Here, we analyzed 2 syngeneic primary human osteosarcoma cell lines that exhibit disparate metastatic potential for differences in epigenetic modifications and expression. Using methylated DNA immunoprecipitation (MeDIP) and microarray  ...[more]

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