Mediating effects of miR-155 on the FceRI signaling responses of mast cells

ABSTRACT: MicroRNA 155 (miR-155) has been shown to regulate the gene expression of important players of physiological and pathological processes, like hematopoietic lineage differentiation, immunity and inflammation, viral infections, cancer and cardiovascular diseases, among others. Degranulation is an event in which mast cells, upon activation of the FceRI, release their granule content rich in vasoactive amines, proteases and TNFa. Additionally activation of the receptor promotes de novo synthesis of cytokines, chemokines and growth factors. Analysis of bone marrow derived mast cells (BMMC) deficient in miR-155 showed a significant increase in FceRI mediated degranulation and in the release of cytokines like TNFa, IL-6 and IL-13. In addition miR 155-/- mice presented higher anaphylaxis reactio

ORGANISM(S): Mus musculus

SUBMITTER: Silvia Bulfone-Paus 

PROVIDER: E-GEOD-56030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress