Different miRNA expression profiles between human breast cancer turmors and serum

ABSTRACT: We identified total 174 significantly differentially expressed miRNAs between tumors and the normal tissues, and 109 miRNAs between serum from patients and serum from healthy individuals. There are only 10 common miRNAs. This suggests that only a small portion of tumor miRNAs are released into serum selectively. Interestingly, the expression change pattern of 28 miRNAs is opposite between breast cancer tumors and serum. Functional analysis shows that the differentially expressed miRNAs and their target genes form a complex interaction network affecting many biological processes and involving in cancer-related pathways such as prostate, basal cell carcinoma, acute myeloid leukymia, and more. A bunch of miRNAs have been demonstrated to be aberrantly expressed in cancer tumor tissue and serum

ORGANISM(S): Homo sapiens

SUBMITTER: ZhaoYun Li 

PROVIDER: E-GEOD-56614 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress