Microarray analysis of H460 parental and H460 holoclone (stem-like cell)-derived tumors

ABSTRACT: BACKGROUND: Cancer stem-like cells were isolated from human H460 non-small cell lung cancer cells by limiting dilution assays and by their holoclone morphology, followed by assessment of their self-renewal capacity, tumor growth, vascularity, and tumor blood perfusion. H460 holoclones were used to implant H460 holoclone-derived tumors, which grew slower than parental H460 tumors, but displayed significant increases in microvessel density and tumor blood perfusion. Microarray analysis identified differentially regulated genes in the holoclone-derived tumors, of which many were associated with angiogenesis. The differentially regulated genes include several small leucine-rich proteoglycans that may modulate angiogenesis and serve as novel therapeutic targets for inhibiting cancer stem ce

ORGANISM(S): Homo sapiens

SUBMITTER: David Waxman 

PROVIDER: E-GEOD-57000 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress