Genome Rearrangements and Pervasive Meiotic Drive Cause Hybrid Infertility in Fission Yeast

ABSTRACT: Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Uncovering the mechanisms of hybrid sterilitynot only provides insight into the origins of species but also potentially revealsnovel causes of intra-species infertility.Here we identify causes underlying hybrid infertilityofSchizosaccharomyces pombeand S. kambucha, two fission yeast species that are 99.5% identical at the nucleotide level.These yeasts mate to form viable diploids that efficiently complete meiosis. However,S. kambucha/S. pombe hybrids generate few viable gametes, most of which are either aneuploid or diploid.We find that chromosomal rearrangements and related recombination defectsare major causes of hybrid infertility. Surprisingly, using experiments in

ORGANISM(S): Schizosaccharomyces kambucha

SUBMITTER: Kyle Fowler 

PROVIDER: E-GEOD-57039 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress