Transcriptome-wide ribonuclease footprinting to identify RNA-protein interaction sites

ABSTRACT: RNA-binding proteins (RBPs) are intimately involved in all aspects of RNA processing and regulation and are linked to neurodegenerative diseases and cancer. Therefore, understanding the relationship between RBPs and their RNA targets is critical for a broader understanding of post-transcriptional regulation in normal and disease processes. The majority of approaches to study RNA-protein interactions focus on single RBPs, however there are many hundreds RBPs encoded in the human genome, and each cell type expresses a different catalog of these regulatory molecules, greatly limiting the ability of these single RBP approaches to capture the global landscape of RNA-protein interactions. We and others have developed approaches to globally catalog regions of mRNAs that are bound by proteins in

ORGANISM(S): Homo sapiens

SUBMITTER: Ian Silverman 

PROVIDER: E-GEOD-57881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress