Polyunsaturated dietary fats decrease mortality and bacterial load during septic S. aureus infection, and improve neutrophil function in mice

ABSTRACT: Severe infections and sepsis is an increasing clinical problem that cause prolonged morbidity and substantial mortality. At present, antibiotics are essentially the only pharmacological treatment for sepsis. The incidence of antibiotic resistance is increasing and it is therefore critical to find new therapies for sepsis. Staphylococcus aureus (S. aureus) is a major cause of septic mortality. Neutrophils play a major role in defense against bacterial infections. We have recently shown that a saturated high fat diet decreases survival in septic mice, but the mechanisms behind remain elusive. The aim of the present study was to investigate how the dietary fat composition affects survival and neutrophils function after experimental septic infection in mice. We found that, after S. aureus inf

ORGANISM(S): Mus musculus

SUBMITTER: Intawat Nookaew 

PROVIDER: E-GEOD-58358 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress