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Proteomic characterization of the effect of CBD in animal models of PWA

ABSTRACT: The effect of CBD was investigated in a preclinical model of PCOS generated by chronic exposure of female mice to DHT from weaning onwards. To exacerbate the metabolic complications in this model, PWA mice were fed a high-fat diet (HFD) for 18 weeks before initiation of the pharmacological treatments. This model phenocopies a subtype of women with this condition who suffer metabolic comorbidities. PWA exacerbated the metabolic disturbances induced by the high-fat diet (HFD), as HFD-fed, non-androgenized female mice exhibited a smaller increase in body weight (BW) compared to androgenized females on the same diet before treatment initiation (Fig. 1A). Daily treatment with CBD for 28 days caused a clear reduction of BW through the treatment period. This datset contains the results of a proteomic characterization of the livers from control mice, PWA mice and CBD treated mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

DISEASE(S): Obesity

SUBMITTER: Martin Garrido

LAB HEAD: Eduardo Munoz

PROVIDER: PXD061045 | Pride | 2025-08-05

REPOSITORIES: Pride

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			Action	DRS
	SOL2024028_14_S4-B4_1_8559.d.zip	Other
	SOL2024028_14_S4-B5_1_8537.d.zip	Other
	SOL2024028_15_S4-B6_1_8529.d.zip	Other
	SOL2024028_16_S4-B7_1_8543.d.zip	Other
	SOL2024028_17_S4-B8_1_8554.d.zip	Other

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1 - 5 of 22

Publications

Cannabidiol improves metabolic profiles and alleviates liver inflammation and fibrosis in conditions of androgenic obesity and polycystic ovary syndrome.

Ponce-Díaz Francisco J FJ Ruiz-Pino Francisco F Garrido-Rodriguez Martín M Prados-González María E ME Uceda-Rodriguez Esperanza E Cerero-Tejero Laura L Guerrero-Ruiz Yolanda Y Sanchez-Garrido Miguel A MA Muñoz Eduardo E Tena-Sempere Manuel M

Diabetes, obesity & metabolism 20250709 10

PMID: 40635171

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