Microarray analysis adherent peripheral blood mononuclear cells stimulated with IL-10, IL-15, and IL-4

ABSTRACT: Tuberculosis remains a major cause of death from an infectious disease worldwide, yet only 10% of people infected with Mycobacterium tuberculosis develop disease. Defining both necessary and sufficient immunologic determinants of protection remains a great scientific challenge. Analysis of peripheral blood gene expression profiles of active tuberculosis patients has identified correlates of risk for disease or pathogenesis. We sought to identify human potential candidate markers of host defense by studying gene expression profiles of macrophages, cells which, upon infection by M. tuberculosis, can mount an antimicrobial response. Weighted gene co-expression network analysis revealed an association between the cytokine, IL-32, and the vitamin D antimicrobial pathway in a network of IFN-

ORGANISM(S): Homo sapiens

SUBMITTER: Dennis Montoya 

PROVIDER: E-GEOD-59184 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress