Gene expression responses to chronic low dose arsenite exposure

ABSTRACT: Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with higher risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disease pathology, little is known about the dynamic cellular changes due to arsenic exposure and withdrawal. In these studies, we seek to understand the molecular mechanisms behind the biological changes induced by chronic low doses of arsenic exposure. We used a comprehensive approach involving chromatin structural studies and mRNA microarray analyses to determine how chromatin structure and gene expression patterns change in response to chronic low dose arsenic exposure and its subsequent withdrawal

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Rouchka 

PROVIDER: E-GEOD-60760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress