Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

ABSTRACT: Upon encounter with antigen, mature B cells undergo complex changes in their physiological state and anatomical localization, and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs), a major effector population of the immune system. To better characterize this process we have defined the transcriptome of all stages of B cell terminal differentiation by performing a large scale RNA-seq experiment. This analysis provides a molecular signature of ASC populations that highlights the stark transcriptional divide between B cells and plasma cells, and also enables the demarcation ASCs based on location, cell cycle status and maturity. The gene expression changes strongly correlated with cell division history and the acquisition of permissive histone modific

ORGANISM(S): Mus musculus

SUBMITTER: Wei Shi 

PROVIDER: E-GEOD-60927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress