Dissecting neural differentiation regulatory networks through epigenetic footprinting

ABSTRACT: Human pluripotent stem cell derived models that accurately recapitulate neural development in vitro and allow for the generation of specific neuronal subtypes are of major interest to the stem cell and biomedical community. Notch signaling, particularly through the Notch effector HES5, is a major pathway critical for the onset and maintenance of neural progenitor cells (NPCs) in the embryonic and adult nervous system1-3. Use of a HES5 reporter enables the isolation distinct populations of human embryonic stem (ES) cell derived NPCs that represent building blocks of cortical development in vitro4. Here, we report the transcriptional and epigenomic analysis of six consecutive stages of human ES cell differentiation along the neural lineage aimed at modeling key cell fate decisions including

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Ziller 

PROVIDER: E-GEOD-62193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress