DNA Methylation and RNA Expression Profiles in Lung Adenocarcinomas [RNA Expression]

ABSTRACT: Lung cancer occurs in never-smokers. Epigenetic changes in lung cancer potentially represent important diagnostic, prognostic, and therapeutic targets. We compared DNA methylation profiles of 28 adenocarcinomas of the lungs of never-smokers with paired adjacent nonmalignant lung tissue. We correlated differential methylation changes with gene expression changes from the same 28 samples. We observed a distinct separation in methylation profiles between tumor and adjacent nonmalignant lung tissue using principal component analysis. Tumors were generally hypomethylated compared with adjacent nonmalignant tissue. Of 1,906 differentially methylated CpG sites between tumor and nonmalignant tissue, 1,198 were within classically defined CpG islands where tumors were hypermethylated compared with n

ORGANISM(S): Homo sapiens

SUBMITTER: Zhifu Sun 

PROVIDER: E-GEOD-62949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress