ADH1 deletion cells upon growth on alternative carbon sources; Steady-state grown cells upon environmental perturbations

ABSTRACT: Cells must adjust their gene expression in order to compete in a constantly changing environment. Two alternative strategies could in principle ensure optimal coordination of gene expression with physiological requirement. First, the internal physiological state itself could feedback to regulated gene expression. Second, the expected physiological state could be inferred from the external environment, using evolutionary-tuned signaling pathways. Coordination of ribosomal biogenesis with the requirement for protein synthesis appears to be particularly important, since cells devote a large fraction of their biosynthetic capacity for ribosomal biogenesis. To define the relative importance of internal vs. external sensing to the regulation of ribosomal biogenesis gene expression, we subjected

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: sagi levy 

PROVIDER: E-GEOD-6302 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress