Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of condition dependent regulation of lipid metabolism in Saccharomyces cerevisiae


ABSTRACT: Investigation of lipid metabolism as a function of three experimental factors: 1) aerobicity (aerobic vs anaerobic, or 'A' vs 'O'), 2) nutrient limitation (carbon vs nitrogen limitation, or 'C' vs 'N'), 3) temperature (30C vs 15C, or 'T' vs 't') using a full factorial design.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Christopher Workman 

PROVIDER: E-MEXP-3704 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mapping condition-dependent regulation of lipid metabolism in Saccharomyces cerevisiae.

Jewett Michael C MC   Workman Christopher T CT   Nookaew Intawat I   Pizarro Francisco A FA   Agosin Eduardo E   Hellgren Lars I LI   Nielsen Jens J  

G3 (Bethesda, Md.) 20131106 11


Lipids play a central role in cellular function as constituents of membranes, as signaling molecules, and as storage materials. Although much is known about the role of lipids in regulating specific steps of metabolism, comprehensive studies integrating genome-wide expression data, metabolite levels, and lipid levels are currently lacking. Here, we map condition-dependent regulation controlling lipid metabolism in Saccharomyces cerevisiae by measuring 5636 mRNAs, 50 metabolites, 97 lipids, and 5  ...[more]

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