Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Alameda
PROVIDER: E-GEOD-63698 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
Menéndez-Gutiérrez María P MP Rőszer Tamás T Fuentes Lucía L Núñez Vanessa V Escolano Amelia A Redondo Juan Miguel JM De Clerck Nora N Metzger Daniel D Valledor Annabel F AF Ricote Mercedes M
The Journal of clinical investigation 20150109 2
Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone loss. Here, we demonstrate that retinoid X receptors (RXRs) are key elements of the transcriptional program of differentiating osteoclasts. Loss of RXR function in hematopoietic cells resulted in formation of giant, nonresorbing osteoclasts and incr ...[more]
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