Elucidating the Linezolid response of Staphylococcus aureus USA300 by a holistic study

ABSTRACT: The translation inhibitor Linezolid is an important antibiotic of last resort against multiresistant gram-positive pathogens including MRSA. Linezolid is reported to specifically inhibit extracellular virulence factors, but the molecular cause is unknown. To elucidate the physiological response of S. aureus to Linezolid in general and the possible inhibition of virulence factors specifically we performed a holistic study. We added Linezolid to logarithmically growing S. aureus cells and analyzed the Linezolid stress response with transcriptomics, quantitative proteomics and microscopy experiments. As previously observed in studies on other translation inhibitors S. aureus is adapting its protein biosynthesis machinery to the reduced translation efficiency, for example the synthesis of ribo

ORGANISM(S): Staphylococcus aureus

SUBMITTER: Florian Bonn 

PROVIDER: E-GEOD-65209 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress