Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and 22q11.2 deletion

ABSTRACT: We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric disorders associated with 22q11.2 microdeletions (del), the most common known schizophrenia (SZ) -associated genetic factor. Several genes in the deleted region have been implicated; one of the more promising candidates is DGCR8, which codes for a protein involved in microRNA (miRNA) biogenesis. We carried out miRNA expression profiling (miRNA-seq) on neurons generated from iPSCs derived from controls and SZ patients with 22q11.2 del. miRNA profiling of 7 SZ samples and 9 Control samples derived from iPSCs

ORGANISM(S): Homo sapiens

SUBMITTER: mingyan lin

PROVIDER: E-GEOD-65367 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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