Methyome profiling in serrated carcinoma

ABSTRACT: Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5 - 8.7% of CRCs. It has been shown that SAC has a worse prognosis and has different molecular and immunohistochemical features compared to conventional carcinoma (CC) but, to date, there is no study analysing its methylome profile. We have investigated the methylation status of 450,000 CpG sites using the Infinium Human Methylation 450 BeadChip array in 103 colorectal specimens from Spanish and Finnish patients. The comparison between the epigenetic signature of 36 SACs and 34 matched CCs was established with the aim of identifying the functions which characterize SAC biology and also the most differentially methylated genes for subsequent validatation by pyrosequencing, methylation-spe

ORGANISM(S): Homo sapiens

SUBMITTER: Patricia Sebastian-Leon 

PROVIDER: E-GEOD-68060 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress